A Painful Lump on the Bottom of Your Foot Shouldn’t Control How You Live

If orthotics and steroid injections haven’t provided lasting relief, you’re not alone. Many people with plantar fibromatosis are still searching for a better option.

A clinical research study is now evaluating a new investigational approach for painful foot nodules caused by plantar fibromatosis.

Takes less than 30 seconds · No personal information required

Study-related care provided at no cost27 research sites across the USActively enrolling

What Is Plantar Fibromatosis?

Plantar fibromatosis, also known as Ledderhose disease, is a condition where firm, fibrous nodules develop along the bottom of the foot. These nodules can grow over time, making it painful to walk, stand, or wear certain shoes. Current options like orthotics, steroid injections, and surgery often provide only temporary relief — and surgery carries a high recurrence rate. This is why clinical research into new approaches is important.

About This Research Study

You May Be a Match If:

How It Works

1

Answer a Few Questions

Complete a brief screening to see if you may be a match for this study.

2

Connect With a Research Site

If you meet the initial criteria, a study site near you will reach out.

3

Begin the Study

The research team will confirm your eligibility and walk you through next steps.

Frequently Asked Questions

Is there any cost to participate?

All study-related visits, procedures, and medication are provided at no cost to participants.

What is a clinical research study?

Clinical research studies evaluate investigational medications or approaches under the supervision of medical professionals. They follow strict protocols overseen by independent ethics review boards.

What happens after I click "See If You May Qualify"?

You’ll be asked to answer some brief screening questions. If you appear to be a potential match, a research site near you will follow up to discuss the study in more detail. There is no obligation to participate.

Where are study sites located?

Research sites are located across the United States. After the initial screening, you’ll be connected with the site closest to you.

Can I withdraw from the study?

Participation is always voluntary. You may withdraw at any time, for any reason.

About Clinical Research

Clinical research studies are an essential part of bringing new medical treatments to patients. Here are a few things to know:

Take the Next Step

See if a plantar fibromatosis research study may be an option for you.

Check If You May Qualify